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THE MECHANISM OF ENZYME-INHIBITOR-SUBSTRATE REACTIONS : ILLUSTRATED BY THE CHOLINESTERASE-PHYSOSTIGMINE-ACETYLCHOLINE SYSTEM.

J Gen Physiol · 1944 · PMC2238027 · PMID 19873399

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may be significantno p-value reported
They dem- onstrated that these systems could operate in three "zones of behavior", and that two of these are commonly neglected in treatments of enzyme kinetics even though they may be significant within the living cell or organism.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.