Intrinsic genetic characteristics determine tumor-modifying capacity of fibroblasts: matrix metalloproteinase-3 5A/5A genotype enhances breast cancer cell invasion.

The higher level of invasion generated in the co-culture assay, though modest in absolute terms, statistically was highly significant ( p = 0.001) and suggests that the concomitant presence of fibroblasts is more stimulatory for invasive activity than conditioned medium alone.

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