Indeed, BORIS has been implicated in the initiation of a series of methylation events at the imprinting control regions, in the vicinity of the CTCF-/BORIS-binding sites ( Jelinic et al , 2006 ), which may be significant for cancer development ( Jelinic and Shaw, 2007 ).
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BORIS, a paralogue of the transcription factor, CTCF, is aberrantly expressed in breast tumours.
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