In further support of a hydrogen peroxide signal, there is a highly significant overlap in the genes altered by MnSOD over-expression and those altered upon direct stimulation with 3% hydrogen peroxide (C Curtis, G Landis, D Skvortsov, D Abdueva, K Tozer, J Tower and S Tavaré, in preparation).
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Transcriptional profiling of MnSOD-mediated lifespan extension in Drosophila reveals a species-general network of aging and metabolic genes.
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