Interestingly, Lcn13 and Fmo3 - which had highly significant S-scores of 11.06 and -6.66, respectively, in the liver of Hfe -/- D2 mice - were confirmed to be regulated by Hfe deficiency in both datasets.
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Gene expression profiling of Hfe-/- liver and duodenum in mouse strains with differing susceptibilities to iron loading: identification of transcriptional regulatory targets of Hfe and potential hemochromatosis modifiers.
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