Loss of dependence on IGF-1 for proliferation of human thyroid adenoma cells.

Br J Cancer · 1988 · PMC2246456 · PMID 3408641

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highly significantno p-value reported

In cultures of normal follicles, whilst neither TSH nor IGF-1 alone produced any effect, a combination of TSH (0.1 mU ml-1) together with IGF-1 (10 ng ml-1) induced a highly significant proliferative response as shown by a peak of 3HTdR incorporation and LI, 4-5 days after growth factor addition.

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