Effect of human recombinant tumour necrosis factor and rat gamma interferon on nitrosomethylurea-induced mammary tumours.

It is interesting, however, that both these agents appeared to cause a reduction in tumour size during the first 4-6 days after administration, before the tumour growth that was observed over the subsequent three weeks (Figures 1 and 2). Repeat dose study (study 2) Animals receiving a single combined dose of rHu-TNF and rat-IFN-y responded in a similar fashion to the animals in study 1, showing highly significant tumour regression at 28 Table I Analysis of combined and single treatment dose data Regression Group No. of No. of New Regression P no.

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