Prediction of 5-fluorouracil cytotoxicity towards the Walker carcinosarcoma using peak integrals of fluoronucleotides measured by MRS in vivo.

In vivo, the alteration of 5FU netabolism caused by HPP, which affected both the FNuct and 5FU peaks, was most evident as a highly significant decrease in the FNuct/5FU ratio at both of the 5FU doses (Table II).

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