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Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer.

Br J Cancer · 2008 · PMC2259187 · PMID 18253113

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a slight trendno p-value reported
We found a slight trend between positive MMP-28 immunostaining and better prognosis of tongue squamous cell carcinoma.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.