Enhancing the prediction of protein pairings between interacting families using orthology information.

BMC Bioinformatics · 2008 · PMC2263026 · PMID 18215279

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In many of these cases, which are highly significant in eukaryotic organisms, the differential interaction of the members of the two families is crucial to explain their biological roles.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.