In contrast to the expression of Ki-67 mRNA, all four hY RNAs reveal either nonsignificant or borderline significant interaction terms ( Table 1 ), indicating a simple additive pattern where, for example, higher expression in cancer and higher expression in tissue X combine to produce very high expression in cancerous tissue X ( Figure 3 ).
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Noncoding human Y RNAs are overexpressed in tumours and required for cell proliferation.
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In the ANOVAs of hY RNAs, the consistently dominant factor is malignancy type ( Table 1 ), which ranges from highly significant (hY4 and hY5) to extremely significant (hY1 and hY3).