Combined expression of caveolin-1 and an activated AKT/mTOR pathway predicts reduced disease-free survival in clinically confined renal cell carcinoma.

Importantly, we go on to demonstrate that increased expression of caveolin-1 when combined with an increase in the expression of activated component(s) of the AKT/mTOR pathway represents a more powerful prognostic determinant than either caveolin-1 alone or activated AKT/mTOR component(s) alone, and is highly significant in multivariate analysis.

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