Two variants among Haemophilus influenzae serotype b strains with distinct bcs4, hcsA and hcsB genes display differences in expression of the polysaccharide capsule.

Of 388 strains isolated during the period 1983–1995 and of 282 strains isolated during the period 1996–2006, a type II associated hcsA gene was found in 20 (5%) and 1 (0.4%) isolates, respectively (Table 2 ), yielding a statistically highly significant difference in distribution (χ 2 , p ≤ 0.001).

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