Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver.

Nucleic Acids Res · 2008 · PMC2275095 · PMID 18158304

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Compared to miR-122 seed sites whose enrichment were statistically highly significant, we observed no enrichment of let-7a seed matches in our dataset, which is in good agreement with specific antagonism of miR-122 by LNA-antimiR leading to de-repression of direct miR-122 targets in the murine liver (Supplementary Table 3).

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