Activity of lapatinib a novel HER2 and EGFR dual kinase inhibitor in human endometrial cancer cells.

Trastuzumab (HerceptinTM) a humanised anti-HER2 antibody has recently been approved for the adjuvant treatment of HER2-overexpressing (3+ IHC) or FISH-positive primary breast cancers based on a highly significant reduction in the risk of recurrence of 52% in node-positive HER2-positive primary breast cancer ( Romond et al , 2005 ).

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