The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth.

When β-catenin expression was scored in these same colon cancers, a highly significant inverse correlation between the level of SIRT1 expression and nuclear β-catenin localization became apparent (p≤0.003, odds ratio 0.24 with 95% confidence interval 0.093–0.63) ( Fig. 5A, B ).

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