Both selective and neutral processes drive GC content evolution in the human genome.

Introns from either light or heavy isochores were then grouped in 6 percentile size classes and their GC 200 analyzed: a significant decrease of GC 200 with increasing residual intron size (intron size calculated after repeat removal) is observed for introns located in heavy isochores while an increasing trend is evident for those located in GC-poor isochores (Figure 3B ).

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