However, it has to be mentioned that at long BCNU exposure times (5 days), IC 50 values for all three BTL cell lines averaged out at about 60–80 μ M (data not shown) whereas differences in case of temozolomide still were highly significant.
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Dynamics of chemosensitivity and chromosomal instability in recurrent glioblastoma.
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Some of these aberrations (losses at chromosomes 2, 6q, and 12q) reached only borderline significance in BTL1 and were distinctly more pronounced in BTL2, whereas other changes (gains at chromosomes 14, 17p, and 20, losses at chromosomes 17q and 18) were completely new in BTL2.