Studies on p53, BAX and Bcl-2 protein expression and microsatellite instability in stage III (UICC) colon cancer treated by adjuvant chemotherapy: major prognostic impact of proapoptotic BAX.

The clinicopathological variables significantly associated with DFS and OS were lymph node category comparing pN1 with pN2-3 (5-year DFS 71.6 vs 49.3%; P =0.001; 5-year OS 80.2 vs 55.7%, P =0.0001), grade of differentiation when subdivided into G1/2 vs G3/4 (5-year DFS 66.8 vs 49.3%; P =0.005; 5-year OS 74.9 vs 55.6%, P =0.003) and treatment arm comparing arm A with arm B (5-year DFS 70.5 vs 53.2%; P =0.01; 5-year OS 76.7 vs 60.7%, P =0.02), whereas T category when subdivided into pT1/2 vs pT3/4 was only of borderline significance in correlation to DFS (5-year DFS 83.9 vs 59.7%, P =0.05).

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Notably, bivariate subgroup analysis showed a nonsignificant trend for survival benefit for patients with the BSI high/MSI+ phenotype as compared to those with the BSI high/MSI− phenotype.

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