However, the benefit of platinum combinations compared to single-agent platinum has long been debated; the analysis published by the Advanced Ovarian Cancer Trialists Group showed that the difference between the two regimens was at the limit of significance (ORR 0.85; CI 95%: 0.72–1.00) ( AOCT, 1991 ).
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Intensified dose of cyclophosphamide with G-CSF support versus standard dose combined with platinum in first-line treatment of advanced ovarian cancer a randomised study from the GINECO group.
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