Comparison of risk patterns in carcinoma and melanoma of the skin in men: a multi-centre case-case-control study.

For freckling we compared subjects with few to several freckles grouped together vs subjects with no freckles: risk of CMM was more than doubled and statistically significant (OR adj 2.3, 95% CI 1.4–3.6), risk of BCC was only borderline significant (OR adj 1.6, 95% CI 1.0–2.5), while no association was found for SCC.

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Hair colour showed a highly significant association for all skin tumours, both considering model deviance when entering it as a multi-category variable ( P -values: 0.0035 for CMM, 0.0027 for BCC and 0.0071 for SCC) or considering P -values for linear trend when entering it as an interval variable ( Table 3 ).

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