Separate analysis of the tissue samples from women bearing BRCA1 mutations ( Figure 4D ) showed that the effects of 0.5 mg E 2 in the absence and presence of TAM or fulvestrant did not quite reach statistical significance ( P =0.084 by Kruskal–Wallis test) although the pattern of changes reflected those seen in the other risk groups.
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Effects of oestrogens and anti-oestrogens on normal breast tissue from women bearing BRCA1 and BRCA2 mutations.
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0.0840
The sentences
The effects of E 2 on PgR expression in tissue from the high-risk group of women also appeared to be altered although the differences between this group and the population risk group just failed to reach significance.