The samples have been split into two sets in order to save DNA and reduce genotyping costs: the first set ( n =2271 cases and 2280 controls) is genotyped for all SNPs and the second set ( n =2203 cases and 2280 controls) is then tested for those SNPs that show marginally significant associations in set 1 ( P -heterogeneity or P -trend <0.1).
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Single-nucleotide polymorphisms in the RB1 gene and association with breast cancer in the British population.
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The sentences
Thus, the observed association is of borderline significance.