Homozygosity for C677T is associated with a reduced risk of colorectal cancer in subjects with good folate status ( Ma et al , 1997 ), suggesting that the impact that folate status has on genomic stability and repair may be significant in the process of malignant transformation and indicating that uracil misincorporation may indeed be an important early cancer biomarker in humans.
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Sensitivity of markers of DNA stability and DNA repair activity to folate supplementation in healthy volunteers.
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