Overexpression of neuropilin-1 promotes constitutive MAPK signalling and chemoresistance in pancreatic cancer cells.

At the therapeutically relevant dose of 50 000 n M , the difference in survival following gemcitabine treatment between NRP-1-overexpressing cells and cells with decreased NRP-1 expression was >50% and highly significant ( P <0.001) ( Figure 6B ).

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