Among postmenopausal women overall, there was a positive trend between adult weight gain and breast cancer risk in all of the tested models, although none of the individual categorical risk estimates reached statistical significance (multivariate adjusted HR by weight change category: 0.75 (CI 0.54, 1.04); 1.0 (reference); 0.98 (CI 0.74, 1.29); 1.01 (CI 0.80, 1.28); 1.00 (CI 0.78, 1.27); 1.12 (CI 0.87, 1.45); 1.22 (CI 0.96, 1.56); trend P =0.002).
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Long-term weight change and breast cancer risk: the European prospective investigation into cancer and nutrition (EPIC).
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