Correlation between the tumoral expression of beta3-integrin and outcome in cervical cancer patients who had undergone radiotherapy.

In a study involving 111 patients with primary malignant melanomas, 71 (64%) were shown to express β 3-integrins ( Hieken et al , 1999 ), and these individuals were more likely to develop lung metastasis and to die of their disease (45% (32 of 71 patients)) than were those with β 3-integrin-negative tumours (8% (three of 40 patients)), a finding that was highly significant ( P <0.0001).

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Nodal status was of borderline significance for DMFS ( P =0.06) and CSS ( P =0.08).

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Lymph-node metastasis, a very potent parameter in the univariate analysis, failed to attain significance for LPFS in Cox's regression model, which is contrary to previous findings of our group ( Burri et al , 2003 ).

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