In addition to there being little effect on normal vasculature there may be significant therapeutic implications in that AW464 may have to be administered chronically or in combination with other agents rather than it being used acutely if it were a tumour vascular targeting agent.
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Cytotoxic and antiangiogenic activity of AW464 (NSC 706704), a novel thioredoxin inhibitor: an in vitro study.
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