Insulin-like growth factor-1 (IGF1) genotype predicts breast volume after pregnancy and hormonal contraception and is associated with circulating IGF-1 levels: implications for risk of early-onset breast cancer in young women from hereditary breast cancer families.

In our study, the body-weight-adjusted breast volumes were larger in parous than in nulliparous women and in hormonal contraceptive users lacking the 19-repeat allele than in non-users, while the opposite was true for women carrying at least one copy of the 19-repeat allele and the interaction was highly significant.

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