Frequent allelic losses at 11q24.1-q25 in young women with breast cancer: association with poor survival.

The role of BRCA1 in the cell cycle has not yet been elucidated, although it has been proposed that the protein of this gene may be significant for the maintenance of the integrity of the genome and that it may interact with Rad51 (Scully et al., 1997), which in turn is known to interact with p53 (Sturzbecher et al, 1996).

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