Loss of Fhit expression in non-small-cell lung cancer: correlation with molecular genetic abnormalities and clinicopathological features.

The remaining 52 lung cancers were characterized by complete absence of cytoplasmic staining (abnormal expression pattern). Admixed non-neoplastic elements served as Fhit-positive internal controls (Figure 1B). Correlation of Fhit expression with tumour histology We found a highly significant correlation between Fhit expression and lung cancer histology (Table 1).

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