Factors predicting efficacy of oxaliplatin in combination with 5-fluorouracil (5-FU) +/- folinic acid in a compassionate-use cohort of 481 5-FU-resistant advanced colorectal cancer patients.

Br J Cancer · 2001 · PMC2364084 · PMID 11506488

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highly significantno p-value reported

correlated with ORR (20% vs 8% for 2 ULN) according to the univariate analysis, it had no independent significance in the multivariate analysis. Biweekly oxaliplatin + 5-FU FA schedules were found to be positively correlated with ORR (29% vs 15% for the triweekly schedules) and was identified as a highly significant factor for the likelihood of objective response in both analyses.

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