However, when the prevalence of muta- tions between centres was examined, a value of P < 0.001 was obtained, suggesting a significant association between centre and mutation rate, perhaps because some centres used more sensitive techniques than others to detect mutations. Results of multivariate analysis The age of the patient was a highly significant factor in our model.
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Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study.
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