Evaluating gene x gene and gene x smoking interaction in rheumatoid arthritis using candidate genes in GAW15.

BMC Proc · 2007 · PMC2367546 · PMID 18466513

Europe PMC DOI

hedged sentence

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

borderline significantp = 0.06so close (0.05 < p ≤ 0.1)

One of the common haplotype of PTPN22 (22222222211221, frequency: 18%) was found to interact with ever smoking at borderline significant level (OR = 0.78, 95%CI: 0.60–1.01, p = 0.06); however, the risk and the protective haplotypes that were identified previously in the case-control sample did not show any departure from multiplicativity with smoking in the case-only study.

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