Incorporating prior biological information in linkage studies increases power and limits multiple testing.

BMC Proc · 2007 · PMC2367562 · PMID 18466592

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extremely significantno p-value reported

This experimental plan proved to be successful on a genome-wide level, with the finding of extremely significant LOD score values for several genes and the presence of both cis and trans regulators as well as so-called "master regulators", or genomic regions where regulators for several genes are mapped.

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