Two-stage strategies to detect gene x gene interactions in case-control data.

BMC Proc · 2007 · PMC2367578 · PMID 18466478

Europe PMC DOI

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closest p · 1.0× alpha

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marginal significancep = 0.05actually significant

In the simultaneous approach, SNPs that fall below the marginal significance thresholds ( p = 0.05 and p = 0.1) in stage 1 are selected and tested for within-group pairwise interaction in stage 2.

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