Relationships between hydrophobicity, reactivity, accumulation and peripheral nerve toxicity of a series of platinum drugs.

To determine whether the accumulation of platinum was related to hydrophobicity, log P was correlated with platinum concentration- time products in neurological tissues, blood and plasma (Figure 3). Highly significant inverse correlations were found between log P and platinum concentration-time products in DRG (r2 = 0.99; P = 0.004), sural nerve (r2 = 0.85; P = 0.025), sciatic nerve (r2 = 0.98; P = 0.0012), brain (r2 = 0.98, P = 0.0011) and spinal cord (r2 = 0.97; P = 0.0018).

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