Finding exonic islands in a sea of non-coding sequence: splicing related constraints on protein composition and evolution are common in intron-rich genomes.

Mirroring results from a comparison of human-mouse orthologues [ 2 ], we found strong and highly significant positive correlations of strikingly linear character (Figure 4 ) between distance from the boundary and amino acid substitution rate for the Drosophila and Caenorhabditis pairs, whilst proximity to the boundary did not appear to confer a higher level of amino acid conservation in the Saccharomyces comparison.

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