Elevated c-Src is linked to altered cell-matrix adhesion rather than proliferation in KM12C human colorectal cancer cells.

A number of studies have demonstrated elevated cellular activity of c-Src, the prototypic member of the Src family of protein tyrosine kinases, during colorectal tumour progression, with an increasing trend from adenomas through to malignant carcinomas and metastases ( Bolen et al , 1987 ; Cartwright et al , 1989 , 1990 , 1994 ; Talamonti et al , 1993 ; Termuhlen et al , 1993 ).

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