Upregulation of cyclooxygenase-2 is accompanied by increased expression of nuclear factor-kappa B and I kappa B kinase-alpha in human colorectal cancer epithelial cells.

Statistical analysis (Wilcoxon's signed rank test) of the matched patient samples ( Figure 2 ) showed that there was a highly significant increase in the mean expression of NF- κ B-p65 between normal and malignant colorectal epithelial cells ( P <0.027).

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