Barely Significant
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Particulate debris from a titanium metal prosthesis induces genomic instability in primary human fibroblast cells.

Br J Cancer · 2003 · PMC2377169 · PMID 12592368

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a definite trendno p-value reported
These values are lower compared to results obtained for radiation ( Kadhim et al , 1997 ) but they show a definite trend towards genomic instability.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.