The parathyroid hormone-related protein receptor is expressed in breast cancer bone metastases and promotes autocrine proliferation in breast carcinoma cells.

Br J Cancer · 2003 · PMC2377170 · PMID 12592371

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may be significantno p-value reported

Since the ERK pathway appears critical for optimal proliferation in MCF-7 cells ( Hermanto et al , 2000 ), the potentiation of its activation by PTHRP may be significant and could provide a further explanation for the enhanced mitogenesis in cells overexpressing the PTHRP-R.

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