Arginine deprivation, growth inhibition and tumour cell death: 2. Enzymatic degradation of arginine in normal and malignant cell cultures.

It was noteworthy, however, that 0.1 units ml −1 brought about cell arrest and the start of cell death after 2 days ( P <0.1) and a highly significant fall by day 4 ( P ≪0.01), indicating persistence of the enzyme as it gradually got to work with time (this enzyme being of higher affinity but lower capacity than arginase).

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