Assessing the evolutionary impact of amino acid mutations in the human genome.

PLoS Genet · 2008 · PMC2377339 · PMID 18516229

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highly significantno p-value reported

This model is 136 log-likelihood units below the maximum of more complex two- and three-parameter models, suggesting additional parameters provide highly significant improvements to the models.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.