The relationship of potential G-quadruplex sequences in cis-upstream regions of the human genome to SP1-binding elements.

We also note that the presence of the zinc finger motif in SP1 may be significant in view of findings that the motif has been selected out from phage libraries to bind to quadruplex DNAs ( 29–31 ), and that transcription factors containing zinc fingers have been reported to bind to G-tract promoter sequences, notably the insulin promoter factor Pur-1/MAZ ( 32 ).

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