A luteinizing hormone receptor intronic variant is significantly associated with decreased risk of Alzheimer's disease in males carrying an apolipoprotein E epsilon4 allele.

Analysis of gene-gene interactions LD analysis In the ADm group but not the Cm group, significant multi-locus LD at the modified FDR level was detected between APOE and lhcgr2 (p = 0.003; α = 0.0077; Table 2 ), while a number of pairs of loci exhibited marginally significant LD (p < 0.05; Table 2 ).

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Both the 'ε4 dosage' and 'ε4 positive' models of APOE genotype were associated with AD at marginally to highly significant levels in AD vs.

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