Large-scale mutagenesis in p19(ARF)- and p53-deficient mice identifies cancer genes and their collaborative networks.

Importantly, we found a large number of highly significant CISs near genes that have not previously been linked to tumorigenesis, including Pik3r5 and Pik3cd , both regulatory subunits of PI3K that upon retroviral activation may enhance PI3K signaling ( Brock et al., 2003 ), miRNA genes like e. g. mmu-mir-24-2/27a/23a and mmu-mir-142 , Lunatic Fringe ( Lfng ), a modulator of Notch receptor activity ( Haines and Irvine, 2003 ) and Smg6 ( Est1a ) which is involved in nonsense-mediated RNA decay ( Fukuhara et al., 2005 ).

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