Gametogenesis in malaria parasites is mediated by the cGMP-dependent protein kinase.

PLoS Biol · 2008 · PMC2408617 · PMID 18532880

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highly significantno p-value reported

By contrast, the greatly decreased sensitivity to compound 1 conferred by the T618Q mutant (>3,000-fold in the recombinant protein) was reflected in a highly significant (analysed by Poisson Regression with Stata 9.2; StataCorp) decrease in inhibitor sensitivity in the parasite.

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