Polymorphisms in prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) and risk of colorectal cancer.

Br J Cancer · 2004 · PMC2409800 · PMID 15173859

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hedged sentences

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

approaches statistical significanceP =0.06so close (0.05 < p ≤ 0.1)

Indeed, the only haplotype that approaches statistical significance (OR=2.17, 95% CI 0.97–4.84, P =0.06) is the one that carries the variant alleles of these two polymorphisms ( Table 3 ).

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marginally significantno p-value reported

Polymorphism PTGS2 .10335 also showed a marginally significant association, but PTGS2 .9850 and PTGS2 .10335 were in tight LD ( r 2 =0.79), and we will focus our discussion on 9850, as it is before the poly-A signal, and therefore more likely to have a functional relevance, while 10335 is after.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.