Elderly patients with fluoropyrimidine and thymidylate synthase inhibitor-resistant advanced colorectal cancer derive similar benefit without excessive toxicity when treated with irinotecan monotherapy.

Br J Cancer · 2004 · PMC2409923 · PMID 15365570

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of borderline significanceno p-value reported

Previous RT has been shown to result in a greater incidence of grades 3–4 diarrhoea with irinotecan ( P =0.046) ( Freyer et al , 2000 ), although this observation was only of borderline significance.

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